翻訳と辞書 Words near each other ・ Peptidase A ・ Peptidase Do ・ Peptide ・ Peptide alpha-N-acetyltransferase ・ Peptide amphiphiles ・ Peptide bond ・ Peptide computing ・ Peptide deformylase ・ Peptide hormone ・ Peptide library ・ Peptide mass fingerprinting ・ Peptide methionine sulfoxide reductase ・ Peptide microarray ・ Peptide nucleic acid ・ Peptide PHI ・ Peptide plane flipping ・ Peptide sequence ・ Peptide sequence tag ・ Peptide spectral library ・ Peptide synthesis ・ Peptide T ・ Peptide transporter 1 ・ Peptide vaccine ・ Peptide YY ・ Peptide-aspartate beta-dioxygenase ・ Peptide-mass fingerprint ・ Peptide-methionine (R)-S-oxide reductase ・ Peptide-methionine (S)-S-oxide reductase ・ Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase ・ Peptide-O-fucosyltransferase Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Peptide plane flipping ： ウィキペディア英語版 Peptide plane flipping Peptide plane flipping is a type of conformational change that can occur in proteins by which the dihedral angles of adjacent amino acids undergo large-scale rotations with little displacement of the side chains. The plane flip is defined as a rotation of the dihedral angles φ,ψ at amino acids ''i'' and ''i+1'' such that the resulting angles remain in structurally stable regions of Ramachandran space. The key requirement is that the ''sum'' of the ψ''i'' angle of residue ''i'' and the φ''i+1'' angle of residue ''i+1'' remain roughly constant; in effect, the flip is a crankshaft move about the axis defined by the Cα-C¹ and N-Cα bond vectors of the peptide group, which are roughly parallel. As an example, the type I and type II beta turns differ by a simple flip of the central peptide group of the turn. Peptide plane flips have been observed in the dynamics of native state protein tertiary structures by comparing crystal structures of the same proteins in multiple conformations. However, the most important role of plane flipping is thought to be in the process of early protein folding rather than native-state local fluctuations. Peptide plane flipping provides a relatively low-energy pathway from alpha sheet or left-handed alpha helix to beta strand conformations. This has been suggested as a mechanism in the conformational changes of amyloid beta and related amyloidogenic peptides implicated in protein misfolding diseases such as Alzheimer's disease. These peptides may pass through an alpha-sheet intermediate in forming the beta-sheet-rich amyloid fiber assembly. ==References== 〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Peptide plane flipping」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.